Bifidobacteria Little Helpers, Big Effects

The immune system is a complex biological system that requires many components to interact properly to protect the body from pathogens and the like. About 70 to 80 percent of immune cells are present in the intestinal lining. In addition to the gut bacteria who are already a resident, probiotics could help to modulate immune response and keep pathogens away.

The tiny intestinal microbial residents will find ideal environmental conditions there and, in turn, they leave little room for pathogenic bacteria, viruses, or fungi. The structure of the intestinal flora therefore offers you a lot of health potential.

The well-known probiotics are lactic acid bacteria and bifidobacteria. They shine with special health-promoting properties and are used to increase the numbers of good bacteria in the intestine and restore the balance of the intestinal flora.

Good to know: not all probiotics are created equal. Each bacterium has specific effects that vary from strain to strain. It is therefore important to select the appropriate probiotic for each intended efficacy for successful product development. MILEI offers the following probiotics in its product portfolio:

BB536: Multifunctional Human Bifidobacteria Strain

Bifidobacterium longum subsp. longum BB536 is one of the most established probiotic strains. It is one of Morinaga's flagships in probiotics and has a proven track record of safety and clinical efficacy1 in improving gastrointestinal, immunological, and infectious conditions, as evidenced by more than 250 scientific studies (as of March 2024).


M-16V: Ideal Probiotic Strain for Infant Health

Bifidobacterium breve M-16V is one of the predominant species present in the infant gut and is widely recognized for its beneficial roles in maintaining infant health2.

It has emerged as one of the best-studied clinically effective probiotic strains that exert positive effects, particularly in infants, to support healthy growth and promote well-being. More than 100 research papers habe been published (as of March 2024)


  • Human-Residential Bifidobacteria: Isolated from healthy infant in 1963
  • Regulatory Approved: FDA notified GRAS status for foods and infant formula in 2013
  • Conducive to healthy growth, anti-infection, anti-allergy, immune development

M-63: Probiotic Strain with Superior Potential for Infant Use

Bifidobacterium longum subsp. infantis M-63 is unique in its ability to utilize Human Milk Oligosaccharides (HMOs)3, the components are highly abundant in human breast milk.

HMOs offer no direct nutritive value for infants, but they function in shaping the infant intestinal microbiota with life-long impacts.


  • Human-Residential Bifidobacteria: Isolated from healthy infant in 1963
  • Regulatory Compliance: FDA notified GRAS status for foods and infant formula in 2022
  • Infant Health, Digestive Health, Anti-Allergy, Mental Health

B-3: Weight Management Probiotics Strain

Bifidobacteria breve B-3 is a unique probiotic strain, developed by focusing on the relationship between gut microbiota and metabolic syndrome.

B-3 possesses an attractive effect in maintaining healthy body weight4 and ultimately improving one’s lifestyle.


  • Human-Residential Bifidobacteria: Isolated from healthy infant in 2002
  • Patented anti-obesity effect in many countries around the world
  • Regulatory Compliance: FDA notified GRAS status for foods in 2022, the approval of Individual Recognized Registration in South Korea for its clinically demonstrated efficacy in body fat reduction in 2023.
  • Healthy body fat composition and metabolic activity


All the products mentioned are:

  • FSSC22000, HALAL, Kosher certified
  • High storage stability
  • Safety ensured through genomic, toxicological, and clinical studies

Find more information here



1 Wong, C. B., Odamaki, T. & Xiao, J.-Z. Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health: Modulation of gut microbiome as the principal action. J. Funct. Foods 54, (2019)
2 Wong, C. B., Iwabuchi, N. & Xiao, J.-Z. Exploring the Science behind Bifidobacterium breve M-16V in Infant Health. Nutrients 11, (2019)
3 Minami, J., Odamaki, T., Hashikura, N., Abe, F. & Xiao, J. Z. Lysozyme in breast milk is a selection factor for bifidobacterial colonisation in the infant intestine. Benef. Microbes 7, 53–60 (2016)
4 Minami, J. et al. Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: A randomized, double-blind, placebo-controlled trial. Biosci. microbiota, food Heal. 1–18 (2018)

Nutrition for Babies and Children Good health from infancy

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Breast milk is the best form of nutrition for infants during their initial stages of development and is therefore recommended without any reservations by the WHO. However, if breastfeeding is not possible, high-quality ingredients are needed to produce infant formula and follow-up products.

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Food Supplements Super, Food!

An ideal diet not only brings a lot of pleasure with it, but also at least as many nutrients and vitamins that are important for the human organism.

Protein bars Compressed Power

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Hypertrophy, rapid regeneration after sports activities, or as a fitness snack— protein bars are in demand with a wide range of functionality, endless flavors and varieties. This is because they are an ideal protein source and help replenish energy reserves.

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Chocolate Sweet Dreams

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Chocolate is popular the world over. This is why a further increase in demand is forecasted— in particular Asia, with India leading the way and Latin America. Overall, consumer focus is on a certain quality of product - an indicator of this are smaller packaging sizes.

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PHD Asuka Tada

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